based simulator Search Results


pbpk simulator simcyp v18  (Simcyp)
90
Simcyp pbpk simulator simcyp v18
Pbpk Simulator Simcyp V18, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pbpk simulator simcyp v18/product/Simcyp
Average 90 stars, based on 1 article reviews
pbpk simulator simcyp v18 - by Bioz Stars, 2026-05
90/100 stars
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population-based adme simulator  (Simcyp)
90
Simcyp population-based adme simulator
Population Based Adme Simulator, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/population-based adme simulator/product/Simcyp
Average 90 stars, based on 1 article reviews
population-based adme simulator - by Bioz Stars, 2026-05
90/100 stars
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vland ca-based simulations  (Vland Biotech Inc)
90
Vland Biotech Inc vland ca-based simulations
Vland Ca Based Simulations, supplied by Vland Biotech Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/vland ca-based simulations/product/Vland Biotech Inc
Average 90 stars, based on 1 article reviews
vland ca-based simulations - by Bioz Stars, 2026-05
90/100 stars
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computer-based simulation  (Simcyp)
90
Simcyp computer-based simulation
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Computer Based Simulation, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/computer-based simulation/product/Simcyp
Average 90 stars, based on 1 article reviews
computer-based simulation - by Bioz Stars, 2026-05
90/100 stars
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finite-element based three-dimensional (3d) simulation  (COMSOL Inc)
90
COMSOL Inc finite-element based three-dimensional (3d) simulation
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Finite Element Based Three Dimensional (3d) Simulation, supplied by COMSOL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/finite-element based three-dimensional (3d) simulation/product/COMSOL Inc
Average 90 stars, based on 1 article reviews
finite-element based three-dimensional (3d) simulation - by Bioz Stars, 2026-05
90/100 stars
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finite-element (fe) based 3-d heating simulation  (COMSOL Inc)
90
COMSOL Inc finite-element (fe) based 3-d heating simulation
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Finite Element (Fe) Based 3 D Heating Simulation, supplied by COMSOL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/finite-element (fe) based 3-d heating simulation/product/COMSOL Inc
Average 90 stars, based on 1 article reviews
finite-element (fe) based 3-d heating simulation - by Bioz Stars, 2026-05
90/100 stars
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numeric simulator silvaco tcad  (Silvaco Inc)
90
Silvaco Inc numeric simulator silvaco tcad
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Numeric Simulator Silvaco Tcad, supplied by Silvaco Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/numeric simulator silvaco tcad/product/Silvaco Inc
Average 90 stars, based on 1 article reviews
numeric simulator silvaco tcad - by Bioz Stars, 2026-05
90/100 stars
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fem-based comsol simulations  (COMSOL Inc)
90
COMSOL Inc fem-based comsol simulations
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Fem Based Comsol Simulations, supplied by COMSOL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fem-based comsol simulations/product/COMSOL Inc
Average 90 stars, based on 1 article reviews
fem-based comsol simulations - by Bioz Stars, 2026-05
90/100 stars
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2-d axis-symmetric finite element method (fem) based electromagnetic simulations  (COMSOL Inc)
90
COMSOL Inc 2-d axis-symmetric finite element method (fem) based electromagnetic simulations
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
2 D Axis Symmetric Finite Element Method (Fem) Based Electromagnetic Simulations, supplied by COMSOL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/2-d axis-symmetric finite element method (fem) based electromagnetic simulations/product/COMSOL Inc
Average 90 stars, based on 1 article reviews
2-d axis-symmetric finite element method (fem) based electromagnetic simulations - by Bioz Stars, 2026-05
90/100 stars
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population-based adme simulator version 21, release 1  (Simcyp)
90
Simcyp population-based adme simulator version 21, release 1
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Population Based Adme Simulator Version 21, Release 1, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/population-based adme simulator version 21, release 1/product/Simcyp
Average 90 stars, based on 1 article reviews
population-based adme simulator version 21, release 1 - by Bioz Stars, 2026-05
90/100 stars
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agent-based epidemiological model  (Johns Hopkins HealthCare)
90
Johns Hopkins HealthCare agent-based epidemiological model
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Agent Based Epidemiological Model, supplied by Johns Hopkins HealthCare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/agent-based epidemiological model/product/Johns Hopkins HealthCare
Average 90 stars, based on 1 article reviews
agent-based epidemiological model - by Bioz Stars, 2026-05
90/100 stars
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comsol-based interference simulations  (COMSOL Inc)
90
COMSOL Inc comsol-based interference simulations
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Comsol Based Interference Simulations, supplied by COMSOL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/comsol-based interference simulations/product/COMSOL Inc
Average 90 stars, based on 1 article reviews
comsol-based interference simulations - by Bioz Stars, 2026-05
90/100 stars
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Image Search Results


Time-course of erlotinib depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Time-course of erlotinib depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Standard Deviation

Area under the concentration-time curve for erlotinib depletion and desmethyl erlotinib formation in primary cultures of human hepatocytes treated with vehicle (DMSO), ritonavir, or ketoconazole and incubated with erlotinib (5 μ M)

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Area under the concentration-time curve for erlotinib depletion and desmethyl erlotinib formation in primary cultures of human hepatocytes treated with vehicle (DMSO), ritonavir, or ketoconazole and incubated with erlotinib (5 μ M)

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Concentration Assay, Incubation

Half-life ( t 1/2 ), % erlotinib metabolized after 48 hours, M/P to AUC ratio, T max of desmethyl erlotinib, and apparent intrinsic clearance (CL int, app ) of erlotinib in primary cultures of human hepatocytes treated with vehicle (DMSO), ritonavir, or ketoconazole and incubated with erlotinib (5 μ M)

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Half-life ( t 1/2 ), % erlotinib metabolized after 48 hours, M/P to AUC ratio, T max of desmethyl erlotinib, and apparent intrinsic clearance (CL int, app ) of erlotinib in primary cultures of human hepatocytes treated with vehicle (DMSO), ritonavir, or ketoconazole and incubated with erlotinib (5 μ M)

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Incubation

Time-course of erlotinib depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), efavirenz (●), or rifampin (□). Data are representative of three individual experiments each performed in duplicate. Error bars represent standard deviation.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Time-course of erlotinib depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), efavirenz (●), or rifampin (□). Data are representative of three individual experiments each performed in duplicate. Error bars represent standard deviation.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Standard Deviation

Area under the concentration-time curve for erlotinib depletion and desmethyl erlotinib formation in primary cultures of human hepatocytes treated with vehicle (DMSO), efavirenz, or rifampin and incubated with erlotinib (5 μ M)

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Area under the concentration-time curve for erlotinib depletion and desmethyl erlotinib formation in primary cultures of human hepatocytes treated with vehicle (DMSO), efavirenz, or rifampin and incubated with erlotinib (5 μ M)

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Concentration Assay, Incubation

Half-life ( t 1/2 ), % erlotinib metabolized after 8 and 24 hours, M/P to AUC ratio, T max of desmethyl erlotinib, and apparent intrinsic clearance (CL int, app ) of erlotinib in primary cultures of human hepatocytes treated with vehicle (DMSO), efavirenz, or rifampin and incubated with erlotinib (5 μ M)

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Half-life ( t 1/2 ), % erlotinib metabolized after 8 and 24 hours, M/P to AUC ratio, T max of desmethyl erlotinib, and apparent intrinsic clearance (CL int, app ) of erlotinib in primary cultures of human hepatocytes treated with vehicle (DMSO), efavirenz, or rifampin and incubated with erlotinib (5 μ M)

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Incubation

Predicted human hepatic or oral clearance (CLhep or CLoral) of erlotinib from primary cultures of human hepatocytes treated with DMSO, ritonavir, or ketoconazole. *P < 0.05 versus DMSO; nonparametric Friedman analysis of variance followed by Dunn’s multiple comparison test.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Predicted human hepatic or oral clearance (CLhep or CLoral) of erlotinib from primary cultures of human hepatocytes treated with DMSO, ritonavir, or ketoconazole. *P < 0.05 versus DMSO; nonparametric Friedman analysis of variance followed by Dunn’s multiple comparison test.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Comparison

Predicted human hepatic or oral clearance (CLhep or CLoral) of erlotinib from primary cultures of human hepatocytes treated with DMSO, efavirenz, or rifampin. *P < 0.05 versus DMSO; nonparametric Friedman analysis of variance followed by Dunn’s multiple comparison test.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Predicted human hepatic or oral clearance (CLhep or CLoral) of erlotinib from primary cultures of human hepatocytes treated with DMSO, efavirenz, or rifampin. *P < 0.05 versus DMSO; nonparametric Friedman analysis of variance followed by Dunn’s multiple comparison test.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Comparison

The parameters used for the prediction of hepatic clearance and the comparisons of observed and predicted CL oral values for erlotinib with prediction errors Observed CL oral values (1.9, 3.3, 1.1, 5.3, 5.75, 4.08) were obtained from literature ( N = 6) ( Messersmith et al., 2004 ; Miller et al., 2007 ; Rudin et al., 2008 ; van Erp et al., 2009 ; Padda et al., 2012 ). Predicted CL oral values (0.853, 0.696, 0.997, 0.793, 0.651, 0.668) were obtained from six different vehicle-treated human hepatocytes.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: The parameters used for the prediction of hepatic clearance and the comparisons of observed and predicted CL oral values for erlotinib with prediction errors Observed CL oral values (1.9, 3.3, 1.1, 5.3, 5.75, 4.08) were obtained from literature ( N = 6) ( Messersmith et al., 2004 ; Miller et al., 2007 ; Rudin et al., 2008 ; van Erp et al., 2009 ; Padda et al., 2012 ). Predicted CL oral values (0.853, 0.696, 0.997, 0.793, 0.651, 0.668) were obtained from six different vehicle-treated human hepatocytes.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques:

Recovery of ritonavir-mediated inhibition (top) and efavirenz-mediated induction (bottom) of erlotinib metabolism in primary cultures of human hepatocytes. Data are representative of three individual experiments each performed in duplicate. Error bars represent standard deviation.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Recovery of ritonavir-mediated inhibition (top) and efavirenz-mediated induction (bottom) of erlotinib metabolism in primary cultures of human hepatocytes. Data are representative of three individual experiments each performed in duplicate. Error bars represent standard deviation.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Inhibition, Standard Deviation